Alzheimer’s Disease Prevention Participant Repository (ADPPR)

What we are studying

The Alzheimer’s Disease Prevention Participant Repository is an observational study that will be used to identify and characterize early risk factors that predict memory decline and dementia in adults with or without early signs of memory impairment. Data will be collected for this study at enrollment and then every 1-2 years thereafter. The data collected will help examine changes in cognitive function, and brain structure and function in older adults with and without a parental family history of Alzheimer’s disease (AD). We will also study how the body processes sugar, and how that may relate to change in brain function over time. The information collected will be stored indefinitely for future analyses.

Who we are studying

• Men and Women
• Races:
  • White
  • African American
  • Asian
  • American Indian or Alaska Native
  • Native Hawaiian or Pacific Islander
  • Other
• All Ethnicities
• Ages 55 - 90

Eligibility Criteria

• Group 1:
  • Healthy volunteer with no diabetes
  • No parental family history of probable Alzheimer’s disease or dementia
  • Both parents must have survived to at least 75 years of age without the onset of symptoms
  • Reliable study partner available to attend Visit 1 at a minimum
• Group 2:
  • Healthy volunteers
  • Parental family history of probable Alzheimer’s disease or dementia
  • Reliable study partner available to attend Visit 1 at a minimum
• Group 3:
  • Mild Cognitive Impairment
  • Reliable study partner available to attend Visit 1 at a minimum
  • No diabetes or pre diabetes
• Group 4:
  • Diagnosis of early-to-mid stage Alzheimer’s Disease
  • Reliable study partner available to attend Visit 1 at a minimum
  • No diabetes or pre diabetes

What is involved

• Blood samples taken
• Tests of memory
• Thinking skills
• Daily functioning and other behaviors
• Tests of balance and physical ability
• Brain scan using magnetic resonance imaging (MRI)
• Blood pressure
• Optional procedures: FDG PET scan to measure glucose activity in the brain; lumbar puncture to collect a sample of the fluid that bathes the brain

Compensation

Travel expenses will be compensated.

Contact Information

Study Coordinator

Tim Collare

Email

rcollare@wakehealth.edu

Phone

336-716-6463

Principal Investigator

Suzanne Craft, PhD