Study of Nasal Insulin to Fight Forgetfulness (SNIFF)

What we are studying

This research is looking at whether a long-lasting type of insulin (insulin detemir) improves memory when administered as a nasal spray into the nasal passages of adults with mild memory impairment or early Alzheimer’s disease. We will explore the effects of nasal administration of both regular insulin and long-lasting insulin on memory and levels of certain hormones and proteins in the blood.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 50 - 89

Eligibility Criteria

  • All participants will be diagnosed with mild cognitive impairment (MCI) or probable Alzheimer's disease (AD)

What is involved

  • Give blood samples (8 times)
  • Take tests of memory and thinking
  • Answer questions about your activities at home (4 times)
  • Receive Magnetic Resonance Imaging (MRI) scan of your brain (2 times)
  • Receive a lumbar puncture (LP) (2 times) and receive an oral glucose tolerance test (OGTT) (2 times)


You will be paid a total of $240 if you complete all the scheduled study visits.

Contact Information

Study Coordinator
Deborah Dahl

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.