What we are studying
In this study, researchers want to find out if we can improve the treatment for this disease by adding another drug called Topotecan to the 5 drugs used in standard treatment. We chose the drug Topotecan because the combination of Topotecan and Cyclophosphamide has been found to be useful in treating some subjects with Ewing sarcoma when it has come back after treatment (recurrence). The combination of vincristine/topotecan/cyclophosphamide (VTC) has been well-tolerated in people with other types of sarcoma. A recent COG study added VTC to standard therapy for localized Ewing sarcoma and the early results indicate that VTC can be used in this way.