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Tumor Biology

Spontaneous Regression of Advanced Cancer in Mice

Microscopic Video of Cellular Activity

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Clip 1 (149 KB)*

Clip 1 (24 KB)**

Downloadable
.avi file***

Video Clip 1: Rupture (necrosis or cytolysis) of cancer cells. The large cells are the S180 cancer cells. The yellow arrow indicates the ruptured cell.

Clip 2 (353 KB)*

Clip 2 (54 KB)**

Downloadable
.avi file***

Video Clip 2: Rupture (necrosis or cytolysis) of cancer cells. Large cells are the S180 cancer cells. The arrow indicates the rupture of the first two cells in a four-cell aggregate of S180 cells.

Clip 3 (517 KB)*

Clip 3 (77 KB)**

Video Clip 3: Rupture (necrosis or cytolysis) of cancer cells. Similar to the experiment described above. Large cells are S180 cells. The arrow indicates the rupture of the last two cells in a four-cell aggregate of S180 cells.

Clip 4 (737 KB)*

Clip 4 (119 KB)**

Video Clip 4: Occasional association of apoptotic events with cell rupture. The cell that is marked by the arrow first undergoes membrane blebbing, then spills out apoptopic bodies; finally the cell ruptures.

Click to watch video over fast connection

Clip 5 (366 KB)*

Clip 5 (56 KB)**

Downloadable
.avi file*** 

Video Clip 5: Killing of a cancer cell by a direct hit with an immune cell. Rupture of the cancer cell (marked by yellow arrow) upon contact with an immune cell from below.
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Video Clips

*To watch the streaming Windows Media (.wmv) video clips on a computer with a broadband connection (such as DSL or cable), click on the links marked with the single asterisk (*). A Windows Media viewing screen should open automatically when you click the icon.

**If you are using a computer with a slower modem or a dial-up connection, click the links marked with the double asterisks (**), and you will be able to see a smaller version of the same video clip. It will be slightly less clear, but will download more quickly.

***You can download the .wmv files (and the much larger .avi file versions where available) by right-clicking the link and selecting 'Save Target As' and saving it to your computer. The .avi files, while much larger, can be opened with QuickTime or other applications.

These video clips were recorded during the series of experiments discussed in the article appearing in the May 27, 2003, issue of Proceedings of the National Academy of Sciences of the USA:

Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice, by Zheng Cui, Mark C. Willingham, Amy M. Hicks, Martha A. Alexander-Miller, Timothy D. Howard, Gregory A. Hawkins, Mark S. Miller, Holly M. Weir, Wei Du, and Cynthia J. DeLong. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6682-7.