Publications

2000 – Present

Porrino LJ, Lyons D. Orbital and medial prefrontal cortex and psychostimulant abuse: studies in animal models. Cerebral Cortex 2000; 10:326-333.

Letchworth SR, Smith JR, Porrino LJ, Bennett BA, Davies HM, Sexton T, Childers SR. Characterization of a tropane radioligand, [(3)H]2β-propanoyl-3β-(4-tolyl) tropane ([3)H]PTT), for dopamine transport sites in rat brain. J Pharmacol Exp Ther 2000; 293(2):686-696.

Freedland CS, Smith HR, Hart SL, Daunais JB, Davies HM, Porrino LJ. A comparison of the behavioral effects of the repeated administration of PTT,2β-propanoyl-3β-(4-tolyl)tropane and cocaine. Brain Res 2000; 869(1 2):98-104.

Freedland CS, Poston J, Porrino LJ. Effects of SR141716A, a novel cannabinoid receptor antagonist on food-maintained responding. Pharmacol Biochem Behav 2001; 67:265-270.

Letchworth SR, Nader MA, Smith HR, Friedman DP, Porrino LJ. Progression of changes in dopamine transporter density as a result of cocaine self-administration in rhesus monkeys. J Neurosci 2001; 21:2799-2807.

Freedland CS, Sharpe AL, Samson HH, Porrino LJ. Effects of SR141716A on ethanol and sucrose self-administration. Alcohol Clin Exp Res 2001; 25:277-282.

Daunais JB, Sim-Selley LS, Letchworth SR, Smith HR, Childers SR, Porrino LJ. Functional and anatomical localization of mu opioid receptors in the primate striatum and extended amygdala. J Comp Neurol 2001; 433:471 485.

Freeman WM, Nader MA, Nader SH, Robertson DJ, Gioia L. Mitchell SM, Daunais JB, Porrino LJ, Friedman DP, Vrana, KE. Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression. J Neurochem 2001; 77:542-549.

Nader MA, Daunais JB, Moore M, Nader S, Moore R, Smith HR, Friedman DP, Porrino LJ. Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology 2002; 27:35-46.

Weiss F, Porrino LJ. Behavioral neurobiology of alcohol addiction: recent advances and challenges. J Neurosci 2002; 22:3332-3337.

Whitlow CT, Freedland CS, Porrino LJ. Metabolic mapping of the time-dependent effects of Δ9-tetrahydro¬cannabinol administration in the rat. Psychopharmacology 2002; 161:129-36.

Freedland CS, Whitlow 9-tetrahydrocannabinol on)CT, Miller M, Porrino LJ. Dose-dependent effects of  rates of local cerebral glucose utilization in rat. Synapse 2002; 45:134-142.

Porrino LJ, Lyons D, Miller MD, Smith HR, Friedman DP, Daunais JB, Nader MA. Metabolic mapping of the effects of cocaine during the initial phases of self-administration in the nonhuman primate. J Neurosci 2002; 22:7687-7694.

Freedland CS, Whitlow CT, Smith HR, Porrino LJ. Functional consequences of the acute administration of the cannabinoid receptor antagonist, SR141716A, in cannabinoid-naïve and tolerant animals: A quantitative 2-[14C]deoxyglucose study. Brain Res 2003; 962:169-179.

Macey DT, Smith HR, Nader MA, Porrino LJ. Chronic cocaine self-administration upregulates the norepinephrine transporter in the bed nucleus of the stria terminalis of the rhesus monkey. J Neurosci 2003; 23:12-16.

Fagergren P, Smith HR, Daunais JB, Nader MA, Porrino LJ, Hurd YL. Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration. Eur J Neurosci 2003; 17:2212-2218.

Whitlow CT, Freedland CS, Porrino LJ. Functional consequences of the repeated administration of ∆9-tetra¬hydro¬cannabinol in the rat. Drug Alcohol Depend 2003; 71:169-177.

Porrino LJ, Daunais JB, Smith HR, Nader MA. The expanding effects of cocaine: Studies in a nonhuman primate model of cocaine self-administration. Neurosci Biobehav Rev 2004; 27:813-820.

Porrino LJ, Lyons D, Smith HR, Daunais JB, Nader MA. Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains. J Neurosci 2004; 24:3554-3562.

Whitlow CT, Liguori A, Livengood LB, Hart SL, Mussat-Whitlow B, Lamborn CM, Laurienti PJ, Porrino LJ. Long-term heavy marijuana users make costly decisions on a gambling task. Drug Alcohol Depend 2004; 76:107-111.

Howlett AC, Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, Porrino LJ. Cannabinoid physiology and pharmacology: Thirty years of progress. Neuropharmacology 2004; 47 Suppl 1:345-358.

Beveridge TJ, Smith HR, Nader MA, Porrino LJ. Functional effects of cocaine self-administration in primate brain regions regulating cardiovascular function. Neurosci Lett 2004; 370(2-3):201-205.

Grobin AC, Vandoren MJ, Porrino LJ, Morrow AL. Cortical 3alpha-hydroxy-5alpha-pregnan-20-one levels after acute administration of Delta9-tetrahydrocannabinol, cocaine and morphine. Psychopharmacology 2005, 179:544-550.

O'Connor KA, Porrino LJ, Davies HM, Childers SR. Time-dependent changes in receptor/G-protein coupling in rat brain following chronic monoamine transporter blockade. J Pharmacol Exp Ther 2005; 313:510-517.

Macey DJ, Rice WN, Freedland CS, Whitlow CT, Porrino LJ. Patterns of functional activity associated with cocaine self-administration in the rat change over time. Psychopharmacology 2004;172:384-392.

Beveridge TJM, Smith HR, Nader MA, Porrino LJ. Effects of chronic cocaine self-administration on norepinephrine transporters in the non-human primate brain. Psychopharmacology 2005; 180:791-788.

Porrino LJ, Daunais JB, Rogers G, Hampson R, Deadwyler SA. Facilitation of cognitive performance and reversal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates. PLoS 2005;3:1639-1652.

Smith HR, Beveridge TJM, Porrino LJ. Distribution of norepinephrine transporters in the non-human primate brain. Neuroscience 2006; 138:703-714.

Beveridge TJM, Smith HR, Daunais JB, Nader MA, Porrino LJ. Chronic cocaine self-administration is associated with altered functional activity in the temporal lobes of nonhuman primates. Eur J Neurosci 2006; 23: 3109-3118.

Smith HR, Beveridge TJ, Porrino LJ. Distribution of norepinephrine transporters in the non-human primate brain. Neuroscience 2006; 138(2):703-714.

Deadwyler SA, Porrino L, Siegel JM, Hampson RE:  Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neuroscience 2007;27:14239-14247.

Porrino LJ, Smith HR, Nader MA, Beveridge TJR. The effects of cocaine: a shifting target over the course of addiction.  Progress in Neuropsychopharmacology and Biological Psychiatry 2007;31:1593-1600.

Smith HR, Porrino LJ.  The comparative distributions of the monoamine transporters in the rodent, monkey, and human amygdala.  Brain, Structure and Function 2008,213:73-91.

Beveridge TJR, Gill KE, Hanlon CA, Nader MA, Porrino LJ. Review.  Parallel studies of neural and cognitive impairment in humans and monkeys.  Philosophical Transactions of the Royal Society B Biological Sciences 2008;363:3257-3266

Smith HR, Beveridge TJR, Hanlon CA, Porrino LJ.  The Dopamine Transporter: An Anatomical Perspective.  In: Dopamine Transporters: Chemistry, Biology and Pharmacology, Issenwasser S., Trudell M. (Eds) John Wiley and Sons, Hoboken, NJ 2008

Hampson RE, España RA, Rogers GA, Porrino LJ, Deadwyler SA. Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717. Psychopharmology 2009; 202: 355-369

Beveridge TJR, Smith HR, Nader MA, Porrino LJ. Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys.  Neuropsychopharmacology 2009;34:1162-1171

Hanlon CA, Wesley MJ, Porrino LJ. Loss of functional specificity in the dorsal striatum of chronic cocaine users.  Drug and Alcohol Dependence 2009: 102:88-94

Hanlon CA, Wesley MJ, Miller MD, Porrino LJ: Motor reorganization in chronic cocaine users: an fMRI investigation of sensorimotor control. Neuropsychopharmacology, 2009, In press.