Apply to Graduate School | Library | Jobs & Volunteers | Visitor Information | Department Index | News      
Research in Lipid Sciences
Dr. Ryan Temel

Ryan E. Temel, PhD

Instructor of Pathology (Lipid Sciences)
Tel: (336) 713-1163
Fax: (336) 716-6279
rtemel@wfubmc.edu

Education:
  • Undergraduate: Allegheny College, Meadvill, PA, 1995
  • Postgraduate: State University of New York at Stony Brook, NY, 2001; Wake Forest University Graduate School of Arts & Sciences
  • Fellowship: Wake Forest University School of Medicine, 2006.  
Interests:
  • Research: Effects of PPAR delta agonists on HDL elevation in non-human primates; molecular and cellular mechanisms of intestinal cholesterol absorption; lipoprotein and hepatic cholesterol metabolism; mouse and non-human primate models of atherosclerosis. 
Current Research: 
  1. Mechanisms for PPAR∂ Agonist-Induced Elevation of High-Density Lipoprotein (HDL) cholesterol in Non-Human Primates
  2. Effects of dietary n-3 fatty acids on intestinal Niemann-Pick C1–like 1 expression and cholesterol absorption
  3. Mechanisms for cholesteryl ester depletion of low-density lipoprotein (LDL) in mice lacking ATP-binding cassette transporter A1 and acyl-CoA:cholesterol acyltransferase 2 
Recent Publications:

Temel RE, Rudel LL. Diet effects on atherosclerosis in mice. Curr Drug Targets. 2007 Nov;8(11):1150-60.

Temel RE, Tang W, Ma Y, Rudel LL, Willingham MC, Ioannou YA, Davies JP, Nilsson LM, Yu L. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest. 2007 Jul;117(7):1968-78.

Temel RE, Hou L, Rudel LL, Shelness GS. ACAT2 stimulates cholesteryl ester secretion in apoB-containing lipoproteins. J Lipid Res. 2007 Jul;48(7):1618-27.

Temel RE, Lee RG, Kelley KL, Davis MA, Shah R, Sawyer JK, Wilson MD, Rudel LL. Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2. J Lipid Res. 2005 Nov;46(11):2423-31

Temel RE, Gebre AK, Parks JS, Rudel LL. Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol. J Biol Chem. 2003 Nov 28;278(48):47594-601.

Temel RE, Parks JS, Williams DL. Enhancement of scavenger receptor class B type I-mediated selective cholesteryl ester uptake from apoA-I(-/-) high density lipoprotein (HDL) by apolipoprotein A-I requires HDL reorganization by lecithin cholesterol acyltransferase. J Biol Chem. 2003 Feb 14;278(7):4792-9.

Temel RE, Walzem RL, Banka CL, Williams DL. Apolipoprotein A-I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI-mediated cholesteryl ester-selective uptake. J Biol Chem. 2002 Jul 19;277(29):26565-72.

Williams DL, Temel RE, Connelly MA. Roles of scavenger receptor BI and APO A-I in selective uptake of HDL cholesterol by adrenal cells. Endocr Res. 2000 Nov;26(4):639-51.

Swarnakar S, Temel RE, Connelly MA, Azhar S, Williams DL. Scavenger receptor class B, type I, mediates selective uptake of low density lipoprotein cholesteryl ester. J Biol Chem. 1999 Oct 15;274(42):29733-9.

Williams DL, Connelly MA, Temel RE, Swarnakar S, Phillips MC, de la Llera-Moya M, Rothblat GH.  Scavenger receptor BI and cholesterol trafficking. Curr Opin Lipidol. 1999 Aug;10(4):329-39. Review.

Rodrigueza WV, Thuahnai ST, Temel RE, Lund-Katz S, Phillips MC, Williams DL.  Mechanism of scavenger receptor class B type I-mediated selective uptake of cholesteryl esters from high density lipoprotein to adrenal cells. J Biol Chem. 1999 Jul 16;274(29):20344-50.

Reaven E, Lua Y, Nomoto A, Temel R, Williams DL, van der Westhuyzen DR, Azhar S. The selective pathway and a high-density lipoprotein receptor (SR-BI) in ovarian granulosa cells of the mouse. Biochim Biophys Acta. 1999 Jan 4;1436(3):565-76.

Reaven E, Nomoto A, Leers-Sucheta S, Temel R, Williams DL, Azhar S. Expression and microvillar localization of scavenger receptor, class B, type I (a high density lipoprotein receptor) in luteinized and hormone-desensitized rat ovarian models. Endocrinology. 1998 Jun;139(6):2847-56.

Temel RE, Trigatti B, DeMattos RB, Azhar S, Krieger M, Williams DL. Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13600-5.

Sung TC, Roper RL, Zhang Y, Rudge SA, Temel R, Hammond SM, Morris AJ, Moss B, Engebrecht J, Frohman MA. Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J. 1997 Aug 1;16(15):4519-30.

Serra MJ, Barnes TW, Betschart K, Gutierrez MJ, Sprouse KJ, Riley CK, Stewart L, Temel RE.  Improved parameters for the prediction of RNA hairpin stability. Biochemistry. 1997 Apr 22;36(16):4844-51.

Rigotti A, Edelman ER, Seifert P, Iqbal SN, DeMattos RB, Temel RE, Krieger M, Williams DL. Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal gland. J Biol Chem. 1996 Dec 27;271(52):33545-9.