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J. Mark Cline, D.V.M., Ph.D.

J. Mark Cline, D.V.M., Ph.D.

Professor, Pathology-Comparative Medicine
Hypertension & Vascular Res Ct
WFU Primate Center
Comprehensive Cancer Center
Contact Information
Office:
336-716-2011
Education & Training
  BSNorth Carolina State University1982
  DVMNorth Carolina State University1986
  PhDNorth Carolina State University1992
Memberships
American Association of Cancer Research
Radiation Research Society
DVM Foundation for the Advancement of Veterinary and Comparative Pathology
Society for Toxicologic Pathology
Veterinary Cancer Society
American Coll of Veterinary Pathologists
American Veterinary Medical Association
J. Mark Cline, D.V.M., Ph.D.

J. Mark Cline, D.V.M., Ph.D.

Professor, Pathology-Comparative Medicine
Hypertension & Vascular Res Ct
WFU Primate Center
Comprehensive Cancer Center
Contact Information
Office:
336-716-2011
Research Interests
human, membranes/tissues/isola, lymphatic & reticulo-endotheli, cancer/oncogenesis, gastrointestinal system, technology /technique developm, women's health issues, cell growth, differentiation,d, instrument development, animals, whole, critical/intensive care medici, animals, cells/membranes/tissu, hematologic system, temporary, growth & development, medical technology/devices, reproductive system, translational research
Recent Publications
Soy consumption and histopathologic markers in breast tissue using tissue microarrays, Nutr Cancer, 11/09/2009

Mammographic density and epithelial histopathologic markers, BMC Cancer, 10/08/2009

Columnar cell lesions in the postmenopausal primate breast [abstract], Toxicol Pathol, 09/29/2009

Hepatic Mallory-Denk body formation in a streptozotocin-treated vervet monkey (Chlorocebus aethiops) [abstract], Toxicol Pathol, 09/28/2009

Diagnostic criteria for peroxisome proliferator-activated receptor (PPAR) agonist-induced urothelial lesions in cynomolgus monkeys [abstract], Toxicol Pathol, 09/24/2009

Guidance for histopathologic detection of endocrine disruption of the female reproductive system in the updated OECD 28-day oral toxicity study in rodents (TG 407) [abstract], Toxicol Pathol, 09/24/2009

Histopathology of the urinary bladders of cynomolgus monkeys treated with PPAR agonists, Toxicol Pathol, 09/24/2009

A monograph on female reproductive pathophysiology in macaques [editorial], Toxicol Pathol, 09/22/2009

Estrogen/isoflavone interactions in cynomolgus macaques (Macaca fascicularis), Am J Primatol, 09/11/2009

Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring, Am J Primatol, 09/11/2009

RasGRP1 transgenic mice develop cutaneous squamous cell carcinomas in response to skin wounding: potential role of granulocyte colony-stimulating factor, Am J Pathol, 09/10/2009

Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone, Menopause, 06/04/2009

Selected background findings and interpretation of common lesions in the female reproductive system in macaques, Toxicol Pathol, 06/04/2009

The mammary glands of macaques, Toxicol Pathol, 06/04/2009

Recommendations for routine sampling, trimming, and paraffin-embedding of female reproductive organs, mammary gland, and placenta in the cynomolgus monkey, Toxicol Pathol, 06/03/2009

The macaque endometrium, with special reference to the cynomolgus monkey {Macaca fascicularis), Toxicol Pathol, 06/03/2009

Summary comparison of female reproductive system in human and the cynomolgus monkey (Macaca fascicularis), Toxicol Pathol, 06/03/2009

Physiology and endocrinology of the ovarian cycle in macaques, Toxicol Pathol, 06/03/2009

Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes, Comp Med, 05/14/2009

Dietary vitamin D exposure reverses the effects of obesity-inducing high-fat diet on premalignant and malignant endometrial changes in Pten+/- mice [abstract], Gynecol Oncol, 05/12/2009

Interactive effects of low-dose estradiol and tamoxifen on the postmenopausal primate endometrium and mammary gland [abstract], Cancer Res, 05/05/2009

Transcriptional profiles of progestogen effects in the postmenopausal breast, Breast Cancer Res Treat, 05/05/2009

Effects of tibolone and conventional HRT on the expression of estrogen and progesterone receptors in the breast, Maturitas, 05/04/2009

Effects of diet and menstrual cyclicity on bone mass accumulation in pubertal monkeys [abstract], J Bone Miner Res, 03/23/2009

Expression of the androgen receptor and syndecan-1 in breast tissue during different hormonal treatments in cynomolgus monkeys, Climacteric, 03/19/2009

Effects of prior oral contraceptive use and soy isoflavonoids on estrogen-metabolizing cytochrome P450 enzymes, J Steroid Biochem Mol Biol, 02/02/2009

Comparative effects of oral conjugated equine estrogens and micronized 17 beta-estradiol on breast proliferation: a retrospective analysis, Menopause, 01/06/2009

Re: Conjugated equine estrogen and risk of benign proliferative breast disease: a randomized controlled trial [letter], J Natl Cancer Inst, 01/06/2009

Past oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis), Cancer Epidemiol Biomarkers Prev, 01/05/2009

Effects of lasofoxifene on the uterus, vagina, and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis), Am J Obstet Gynecol, 11/04/2008

Cystic mammary adenocarcinoma associated with a prolactin-secreting pituitary adenoma in a New Zealand white rabbit (Oryctolagus cuniculus), Comp Med, 10/22/2008

Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland, Lab Invest, 10/22/2008

Polycystic ovary syndrome with endometrial hyperplasia in a cynomolgus monkey (Macaca fascicularis), Vet Pathol, 10/02/2008

In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids, J Biol Chem, 08/14/2008

Progestin treatment induces apoptosis and modulates transforming growth factor-beta in the uterine endometrium, Cancer Epidemiol Biomarkers Prev, 06/03/2008

Effects of testosterone therapy in combination with oral estradiol and progesterone on breast proliferation and serum lipids in a postmenopausal primate model [abstract], Menopause, 04/10/2008

Life stage differences in mammary gland gene expression profile [abstract], Menopause, 04/08/2008

RasGRP1 overexpression in the epidermis of transgenic mice contributes to tumor progression during multistage skin carcinogenesis, Cancer Res, 12/13/2007

Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys, Psychoneuroendocrinology, 12/13/2007

Mammary gland development in early pubertal female macaques, Toxicol Pathol, 12/12/2007

Progressive left ventricle, myocyte dysfunction, and heart failure in the lethality of anthrax toxin in conscious dogs [abstract], Circulation, 12/12/2007

Cystic mammary adenocarcinoma associated with a prolactin-secreting pituitary adenoma in a New Zealand white rabbit (Oryctolagus cuniculus) [abstract], J Am Assoc Lab Anim Sci, 12/07/2007

Intramuscular administration of 4-vinylcyclohexene diepoxide (VCD) destroys primordial follicles in adult Sprague Dawley rats (Rattus norvegicus) [abstract], J Am Assoc Lab Anim Sci, 11/19/2007

Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model, Menopause, 10/12/2007

Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids, J Clin Invest, 10/04/2007

Uterine infarctions in cynomolgus monkeys (Macaca fascicularis), Vet Pathol, 07/24/2007

Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys, Carcinogenesis, 07/13/2007

Characterization and experimental transmission of an oncogenic papillomavirus in female macaques, J Virol, 07/11/2007

Assessing the mammary gland of nonhuman primates: effects of endogenous hormones and exogenous hormonal agents and growth factors, Birth Defects Res B Dev Reprod Toxicol, 06/27/2007

Tibolone: example of qualitative and quantitative assessments of the mammary gland, Birth Defects Res B Dev Reprod Toxicol, 06/27/2007

A macaque model for cervical cancer [abstract], Am J Primatol, 06/22/2007

Estrogen/isoflavone interactions in cynomolgus macaques (Macaca fascicularis) [abstract], Am J Primatol, 06/22/2007

Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis), J Nutr, 06/14/2007

Progestin induces apoptosis and modulates transforming growth factor beta in the endometrium: toward a mechanism for chemoprevention [abstract], Gynecol Oncol, 06/06/2007

Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2, Cancer Res, 06/05/2007

Androgen production in the cynomolgus monkey ovary [abstract], Menopause, 04/17/2007

Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys, Breast Cancer Res Treat, 04/12/2007

Effects of two novel selective estrogen receptor modulators, raloxifene, tamoxifen, and ethinyl estradiol on the uterus, vagina and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis), Am J Obstet Gynecol, 03/28/2007

Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance?, J Lipid Res, 02/02/2007

Effects of soybean glyceollins and estradiol in postmenopausal female monkeys, Nutr Cancer, 01/22/2007

Effects of high-dose soy lsoflavones and equol on reproductive tissues in female cynomolgus monkeys, Biol Reprod, 11/13/2006

Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition, Fertil Steril, 11/08/2006

Hormonal effects on the mammary gland of postmenopausal nonhuman primates, Breast Dis, 10/27/2006

Hyperplastic and neoplastic lesions of the mammary gland in macaques, Vet Pathol, 10/26/2006

Histologic and immunohistochemical characterization of spontaneous pituitary adenomas in fourteen cynomolgus macaques (Macaca fascicularis), Vet Pathol, 10/13/2006
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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