Education:
- DVM (2001). Virginia-Maryland Regional College of Veterinary Medicine; Virgina Tech, Blacksburg, VA.
- Postdoctoral Fellowship and Veterinary Pathology Residency (2002-2005). Wake Forest University School of Medicine.
- PhD (2006). Molecular and Cellular Pathobiology; Wake Forest University Graduate School of Arts and Sciences.
Current Research:
Dr. Cann’s research focuses on the effect of interrupted estrogen exposure on atherosclerosis. It is widely held that relative estrogen deficiency is associated with enhanced atherogenesis and increased risk of coronary heart disease. However, reintroduction of estrogen in women after a significant duration of estrogen deficiency does not appear to decrease and may increase the risk of coronary heart disease. Thus, reintroduction of estrogen to an estrogen deficient woman may carry with it its own set of cardiovascular risks. Atherosclerosis is known to be a chronic inflammatory disease and estrogenic compounds, with or without the addition of a progestin, modulate the inflammatory response in postmenopausal women. Estrogens act on different components of the vascular wall, including the endothelium, smooth muscle cells, and leukocytes, and the involved signaling cascades are integral parts of the inflammatory response. Under the direction of Dr. Koudy Williams, Dr. Cann has been using a mouse model of atherosclerosis in which treatment groups are exposed to varying periods of estrogen replacement and/or deficiency to test the hypothesis that while interrupted estrogen exposure has little effect on atherosclerosis extent per se, estrogen deficiency followed by reintroduction will result in atherosclerotic lesions with cellular, extracellular, and molecular characteristics associated with increased plaque instability.
Recent Publications:
Cann JA, Register TC, Adams MR, St. Clair RW, Espeland MA, Williams JK. Timing of Estrogen Replacement Influences Atherosclerosis Progression and Plaque Leukocyte Populations in ApoE-/- Mice. Submitted September 2006.
Cann JA, Cline JM, St. Clair RW, Williams JK. Augmentation of CRP and MMP-9 in Advanced Atherosclerotic Lesions in Cynomolgus Macaques (Macaca fascicularis). Submitted September 2006.
Remick AK, Wood CE, Cann JA, Gee MK, Feiste EA, Kock ND, Cline JM. Histologic and Immunohistochemical Characterization of Spontaneous Pituitary Adenomas in 13 Cynomolgus Macaaques (Macaca fascicularis). Vet Pathol. 2006; 43(4):484-93.
Register TC, Cann JA, Kaplan JR, Williams JK, Adams MR, Morgan TM, Anthony MS, Blair RM, Wagner JD, Clarkson TB. Effects of soy isoflavones and conjugated equine estrogens on inflammatory markers in atherosclerotic, ovariectomized monkeys. J Clin Endocrinol Metab. 2005 Mar;90(3):1734-40.
Abstracts:
- Cann JA, Cline JM, St.Clair RW, Williams JK. Augmentation of CRP and MMP-9 in Advanced Atherosclerotic Lesions in Cynomolgus Macaques (Macaca fascicularis). American College of Veterinary Pathologists. 57th Annual Meeting. December 2-6, 2006. Tucson, Arizona.
- Cann JA, Kock ND, Trybus J, Gee MK. Fatal Melioidosis in Two Recently Imported Cynomolgus Macaques (Macaca fascicularis). American College of Veterinary Pathologists. 56th Annual Meeting. December 3-7, 2005. Boston, Massachusetts.
- Remick AK, Wood CE, Cann JA, Feiste EA, Cline JM, and Kock ND. Histologic and Immunohistochemical Characterization of Spontaneous Pituitary Adenomas in 13 Cynomolgus Macaques (Macaca fascicularis). American College of Veterinary Pathologists. 55th Annual Meeting. November 13-17, 2004. Orlando, Florida.
- Cann JA, Gee MK, Kock ND. Unusual Presentation of a T-Cell Rich B-Cell Lymphoma in a Rhesus Macaque (Macaca mulatta). Association of Primate Veterinarians Annual Workshop. October 14-17, 2004. Tampa, Florida.
Case Reports:
- Cann JA, Kock ND. T-Cell Rich B-Cell Lymphoma in a Rhesus Macaque (Macaca mulatta). Armed Forces Institute of Pathology Wednesday Slide Conference. 2004-2005. Washington, DC.
- Cann JA, Cline JM, Kock ND. Membranous Glomerulonephropathy in an Outbred nu/nu Mouse. Armed Forces Institute of Pathology Wednesday Slide Conference. 2003-2004. Washington, DC.
Professional Memberships:
Presentations and Awards:
Oral Presentations:
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Cann JA, Cline JM. Gonadotroph Hypertrophy and Hyperplasia in a Postmenopausal Cynomolgus Macaque (Macaca fascicularis). Primate Pathology Workshop 2004. October 18-19, 2004. Wake Forest University School of Medicine, Winston-Salem, North Carolina.
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Cann JA, Gee MK, Kock ND. Unusual Presentation of a T-Cell Rich B-Cell Lymphoma in a Rhesus Macaque (Macaca mulatta). Association of Primate Veterinarians Annual Workshop. October 14-17, 2004. Tampa, Florida.
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Cann JA, Cline JM. Atherosclerosis in an 18-Year Old Cynomolgus Macaque (Macaca fascicularis). Primate Pathology Workshop 2003. October 22, 2003. University of Washington, Seattle, Washington.
Poster Presentations:
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Cann JA, Cline JM, St.Clair RW, Williams JK. Augmentation of CRP and MMP-9 in Advanced Atherosclerotic Lesions in Cynomolgus Macaques (Macaca fascicularis). American College of Veterinary Pathologists, 57th Annual Meeting. December 2-6, 2006. Tuscon, AZ.
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Cann JA, Kock ND, Trybus J, Gee MK. Fatal Melioidosis in Two Recently Imported Cynomolgus Macaques (Macaca fascicularis). American College of Veterinary Pathologists. 56th Annual Meeting. December 3-7, 2005. Boston, Massachusetts.
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Remick AK, Wood CE, Cann JA, Feiste EA, Cline JM, and Kock ND. Histologic and Immunohistochemical Characterization of Spontaneous Pituitary Adenomas in 13 Cynomolgus Macaques (Macaca fascicularis). American College of Veterinary Pathologists. 55th Annual Meeting. November 13-17, 2004. Orlando, Florida.
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Cohen KA, Cann JA, Kock ND, Cline JM. Severe Anasarca in Four Outbred nu/nu Mice With Membranous Glomerulonephropathy. American Association for Laboratory Animal Science, 54th Annual Meeting. October 12-16, 2003, Seattle, Washington.
Awards: