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Comparative Medicine
Dr. Susan Appt

Susan E. Appt, DVM

Assistant Professor of Pathology (Comparative Medicine)
Tel: (336) 716-1637
Fax: (336) 716-1515
sappt@wfubmc.edu

Education:
  • Undergraduate: Nova Scotia Agricultural College, 1987-1990
  • Postgraduate: Atlantic Veterinary College, 1990-1994
  • Fellowship: Pathology (Comparative Medicine) Wake Forest University School of Medicine, 2001-2004
Interests:
  • Research: Hormone changes during menopausal transition and chronic diseases common in postmenopausal women. 
Current Research: 

Dr. Appt's research interests focus on using nonhuman primates to better understand the influence of hormone changes during the menopausal transition and how those changes affect risk factors for chronic diseases common in postmenopausal women.

Current projects include the characterization of the nonhuman primate model of perimenopause, studies of the effects of hormonal changes across the perimenopausal transition on risk factors for cardiovascular disease and bone loss, and the development of imaging modalities to non-invasively track ovarian failure in nonhuman primates. 

Publications:

More recent publications are listed on PubMed [Link]

Törmälä R, Appt SE, Clarkson TB, Tikkanen MJ, Ylikorkala O, Mikkola TS. Individual differences in equol production capability modulate blood pressure in tibolone-treated postmenopausal women. Climacteric 2007;10:471–479.

Törmälä R, Appt S, Clarkson TB, Groop PH, Rönnback M, Ylikorkala O, Mikkola TS. Equol production capability is associated with favorable vascular function in postmenopausal women using tibolone; no effect with soy supplementation. Atherosclerosis. 2008 May;198(1):174-8.

Jones JC, Appt SE, Bourland JD, Hoyer PB, Clarkson TB, Kaplan JR. Multidetector computed tomographic morphology of ovaries in cynomolgus macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2007 Sep;46(5):54-63.

Wood CE, Clarkson TB, Appt SE, Franke AA, Boue SM, Burow ME, McCoy T, Cline JM. Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Nutr Cancer. 2006;56(1):74-81. 

Appt SE, Kaplan JR, Clarkson TB, Cline JM, Christian PJ, Hoyer PB. Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition. Fertil Steril. 2006 Oct;86 Suppl 4:1210-6.

Stroud FC, Appt SE, Wilson ME, Franke AA, Adams MR, Kaplan JR. Concentrations of isoflavones in macaques consuming standard laboratory monkey diet. J Am Assoc Lab Anim Sci. 2006 Jul;45(4):20-3.

Wood CE, Appt SE, Clarkson TB, Franke AA, Lees CJ, Doerge DR, Cline JM.  Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biol Reprod. 2006 Sep;75(3):477-86.

Appt SE, Clarkson TB, Lees CJ, Anthony MS. Low dose estrogens inhibit coronary artery atherosclerosis in postmenopausal monkeys. Maturitas. 2006 Sep 20;55(2):187-94.

Badeau M, Tikkanen MJ, Appt SE, Adlercreutz H, Clarkson TB, Hoikkala A, Wahala K, Mikkola TS.  Determination of plasma genistein fatty acid esters following administration of genistein or genistein 4'7-O-dioleate in monkeys. Biochim Biophys Acta. 2005 Dec 30;1738(1-3):115-20.

Clarkson TB, Appt SE. Controversies about HRT--lessons from monkey models. Maturitas. 2005 May 16;51(1):64-74. Review.

Clarkson TB, Appt SE, Wood CE, Cline JM. Lessons to be learned from animal studies on hormones and the breast. Maturitas. 2004 Sep 24;49(1):79-89. Review.

Appt SE.  Usefulness of the monkey model to investigate the role soy in postmenopausal women's health. ILAR J. 2004;45(2):200-11. Review.

Pazol K, Kaplan JR, Abbott D, Appt SE, Wilson ME. Practical measurement of total and bioavailable estradiol in female macaques. Clin Chim Acta. 2004 Feb;340(1-2):117-26.

Clarkson TB, Appt SE. MPA and postmenopausal coronary artery atherosclerosis revisited. Steroids. 2003 Nov;68(10-13):941-51. Review.

Blair RM, Appt SE, Franke AA, Clarkson TB. Treatment with antibiotics reduces plasma equol concentration in cynomolgus monkeys (Macaca fascicularis). J Nutr. 2003 Jul;133(7):2262-7.

Blair RM, Appt SE, Bennetau-Pelissero C, Clarkson TB, Anthony MS, Lamothe V, Potter SM. Dietary soy and soy isoflavones have gender-specific effects on plasma lipids and isoflavones in golden Syrian f(1)b hybrid hamsters. J Nutr. 2002 Dec;132(12):3585-91.