Profile

Leslie B. Poole, Ph.D.

Leslie B. Poole, Ph.D.

Professor, Biochemistry
Comprehensive Cancer Center
Translational Institute
Translational Institute
Contact Information
Office:
336-716-6711
Email: lbpoole@wfubmc.edu
Research Interests
technology /technique developm, information sciences, urinary system/kidney, basic mechanisms, biological/chemical compounds, molecular biology/molecular me, cell growth, differentiation,d, infectious diseases, educational service, biotechnology, computer science, microorganisms, structural biology
Recent Publications
Typical 2-Cys peroxiredoxins--structures, mechanisms and functions. Hall A, Karplus PA, Poole LB. FEBS J. 2009 276(9) : 2469-2477


Structural changes common to catalysis in the Tpx peroxiredoxin subfamily. Hall A, Sankaran B, Poole LB, Karplus PA. J Mol Biol. 2009 393(4) : 867-881


Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds. Hall A, Parsonage D, Horita D, Karplus PA, Poole LB, Barbar E. Biochemistry. 2009 48(25) : 5984-5993


Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity. Yamamoto Y, Ritz D, Planson A-G, Jonsson TJ, Faulkner MJ, Boyd D, Beckwith J, Poole LB. Mol Cell. 2008 29(1) : 36-45


Discovering mechanisms of signaling-mediated cysteine oxidation. Poole LB, Nelson KJ. Curr Opin Chem Biol. 2008 12(1) : 18-24


Cysteine pKa values for the bacterial peroxiredoxin AhpC. Nelson KJ, Parsonage D, Hall A, Karplus A, Poole LB. Biochemistry. 2008 47(48) : 12860-68


Detection of cysteine sulfenic acid formation: role in reactive oxygen species-dependent VEGF signaling linked to endothelial migration [abstract]. Nakamura Y, Kaplan N, Poole LB, Fukai T, Ushio-Fukai M. Circulation. 2008 118(18 Suppl 2) : S273


Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pKa values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Nelson KJ, Day AE, Zeng B-B, King SB, Poole LB. Anal Biochem. 2008 375(2) : 187-195


Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin. Parsonage D, Karplus PA, Poole LB. Proc Natl Acad Sci U S A. 2008 105(24) : 8209-8214


Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H2O2. Smith-Pearson PS, Kooshki M, Spitz DR, Poole LB, Zhao W, Robbins ME. Free Radic Biol Med. 2008 45(8) : 1178-1189


Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase. Hutson SM, Poole LB, Coles S, Conway ME. Methods Mol Biol. 2008 476 : 139-152


Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid. Salsbury FR Jr, Knutson ST, Poole LB, Fetrow JS. Protein Sci. 2008 17(2) : 299-312


Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins. Poole LB, Klomsiri C, Knaggs SA, Furdui CM, Nelson KJ, Thomas MJ, Fetrow JS, Daniel LW, King SB. Bioconjug Chem. 2007 18(6) : 2004-2017


The shuffle index and evaluation of models of signal transduction pathways. Allen EE, Diao L, Fetrow JS, John DJ, Loeser RF, Poole LB. Proceedings of the 45th Annual ACM Southeast Regional Conference; 2007 Mar 23-24; Winston-Salem (NC). 2007 : 250-255


Cysteine reactivity and thiol-disulfide interchange pathways in AhpF and AhpC of the bacterial alkyl hydroperoxide reductase system. Jonsson TJ, Ellis HR, Poole LB. Biochemistry. 2007 46(19) : 5709-5721


The role of cysteine sulfenic acid formation during NF-kappa B-mediated signaling [abstract]. Nelson KJ, Klomsiri C, Rogers RL, Daniel LW, Poole LB. Free Radic Biol Med. 2007 43(Suppl 1) : S156


Substrate specificity and chemical characterization of a bacterial peroxiredoxin, AhpC [abstract]. Parsonage D, Nelson KJ, Day AE, Poole LB. Free Radic Biol Med. 2007 43(Suppl 1) : S113


Sulfenic acid-reactive compounds and their methods of synthesis [patent]. King SB, Poole L, Fetrow J, inventors. Wake Forest University Health Sciences, assignee; US patent 7,294,748; 2007 Nov 13;. 2007


The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. Michalek RD, Nelson KJ, Holbrook BC, Yi JS, Stridiron D, Daniel LW, Fetrow JS, King SB, Poole LB, Grayson JM. J Immunol. 2007 179(10) : 6456-6467


The catalytic mechanism of peroxiredoxins. Poole LB. Subcell Biochem. 2007 44 : 61-81


Cysteine sulfenic acid detection in signal transduction pathways [abstract]. Klomsiri C, Nelson KJ, Naggs SA, Fetrow JS, King SB, Furdui CM, Poole LB. Free Radic Biol Med. 2007 43(Suppl 1) : S157


Chondrocyte MMP-13 expression in response to alpha 5 beta 1 integrin stimulation requires protein sulfenic acids as signaling intermediates [abstract]. Loeser RF, Yammani R, Erickson E, King B, Poole L. Arthritis Rheum. 2006 54(9 Suppl) : S318


Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery. Phalen TJ, Weirather K, Deming PB, Anathy V, Howe AK, van der Vliet A, Jonsson TJ, Poole LB, Heintz NH. J Cell Biol. 2006 175(5) : 779-789
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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