Profile

Frank M.  Torti, M.D.

Frank M. Torti, M.D.

Vice President, Strategic Programs, Wake Forest University Baptist Medical Center
Charles L. Spurr Professor, Hematology & Oncology
Cancer Biology
Urology
Institute for Regenerative Medicine
Contact Information
Appointment:
336-713-5440
Office:
336-716-7971
Fax:
336-716-5687
Clinical Specialties
Genitourinary Oncology
Education & Training
  BAJohns Hopkins University1969
  MAJohns Hopkins University1969
  MPHHarvard School of Public Health1973
  MDHarvard Medical School1974
ResidencyMedicineBeth Israel Deaconess Med Ctr1976
InternshipMedicineBeth Israel Deaconess Med Ctr1975
FellowshipStanford University School of Medicine1979
Board Certifications
American Board of Internal Medicine , Medical Oncology
American Board of Internal Medicine , Internal Medicine
Memberships
American Urological Association
International Bioiron Society
American Association of Advancement of Science
American Coll of Physicians
American Society of Hematology
Int'L Society of Interferon Research
Society for Free Radical Biology and Medicine
American Federation of Clinical Research
North Carolina Medical Society
American Society of Cell Biology
American Society of Clinical Oncology
American Medical Association
American Association of Cancer Research
NPI Number
1134180698
Frank M.  Torti, M.D.

Frank M. Torti, M.D.

Vice President, Strategic Programs, Wake Forest University Baptist Medical Center
Charles L. Spurr Professor, Hematology & Oncology
Cancer Biology
Urology
Institute for Regenerative Medicine
Contact Information
Appointment:
336-713-5440
Office:
336-716-7971
Fax:
336-716-5687
Research Interests
basic mechanisms , cancer/oncogenesis , clinical trials , education/training (all f, t, , educational service , facility construction/infrastr , health services/training , information sciences , technology /technique developm
Recent Publications
Chaosuwannakit N, D'Agostino R Jr, Hamilton CA, Lane KS, Ntim WO, Lawrence J, Melin SA, Ellis LR, Torti FM, Little WC, Hundley WG. Aortic stiffness increases upon receipt of anthracycline chemotherapy. J Clin Oncol. 2010; 28(1):166-172.


Li L, Fang CJ, Ryan JC, Niemi EC, Lebron JA, Bjorkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, et al. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010; 107(8):3505-3510.


Hamilton C, Hundley G, Morgan T, Lane K, Torti F. Non-invasive systems and methods for the determination of cardiac injury using a characterizing portion of a Voxel histogram. United States patent US 7,747,308. 2010 June 29. 2010; ():.


Burke A, Carroll D, Torti FM, Torti SV. Bi-functional nanomaterials for the imaging and treatment of cancer. In: Narlikar AV, Fu YY, eds. Oxford handbook of nanoscience and technology, vol 3:applications. Oxford (UK): Oxford University Press; 2010: 474-497.


Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev. 2009; 23(3):95-104.


Xu J, Kibel AS, Turner AR, Pruett K, Zheng SL, Sun J, Kim S-T, Hsu F-C, Torti FM, Chang B-L, et al. Prostate cancer risk associated loci in African Americans. Cancer Epidemiol Biomarkers Prev. 2009; 18(7):2145-2149.


Hatcher HC, Singh RN, Torti FM, Torti SV. Synthetic and natural iron chelators: therapeutic potential and clinical use. Future Med Chem. 2009; 1(9):1643-1670.


Storey JA, Connor RF, Lewis ZT, Hurd D, Pomper G, Keung YK, Lovato J, Torti SV, Torti FM, Molnar I, et al. The transplant iron score as a predictor of stem cell transplant survival. J Hematol Oncol. 2009; 2():article 44.


Burke A, Singh R, Kraft RA, Levi-Polyachenko N, Hatcher HC, D'Agostino R Jr, Kock ND, Carroll DL, Akman S, Torti FM, Torti SV, et al. Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proc Natl Acad Sci U S A. 2009; 106(31):12897-902.


Hower V, Mendes P, Torti FM, Laubenbacher R, Akman S, Shulaev V, Torti SV. A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst. 2009; 5(5):422-443.


Jiao Y, Wilkinson J IV, Di X, Wang W, Hatcher H, Kock ND, D'Agostino R Jr, Knovich MA, Torti FM, Torti SV. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood. 2009; 113(2):462-469.


Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I study of angiotensin-(1-7), an endogenous antiangiogenic hormone: clinical, pharmacokinetic, and biomarker findings [abstract]. Mol Cancer Ther. 2009; 8(12 Suppl 1):B208.


Laubenbacher R, Hower V, Jarrah A, Torti SV, Shulaev V, Mendes P, Torti FM, Akman S. A systems biology view of cancer. Biochim Biophys Acta. 2009; 1796(2):129-139.


Coffman LG, Parsonage D, D'Agostino RD Jr, Torti FM, Torti SV. Regulatory effects of ferritin on angiogenesis. Proc Natl Acad Sci U S A. 2009; 106(2):570-575.


Chaosuwannakit N, D'Agostino R Jr, Hamilton CA, Lane KS, Ntim WO, Lawrence J, Melin SA, Ellis LR, Torti FM, Little WC, Hundley WG. Subclinical cardiovascular toxicity of anthracyclines identified with cardiovascular magnetic resonance imaging [abstract]. Circulation. 2009; 120(18 Suppl):S299.


Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I and pharmacokinetic study of angiotensin-(1-7), an endogenous antiangiogenic hormone. Clin Cancer Res. 2009; 15(23):7398-7404.


Stadler WM, Desai AA, Quinn DI, Bukowski R, Poiesz B, Kardinal CG, Lewis N, Makalinao A, Murray P, Torti FM. A phase I/II study of GTI-2040 and capecitabine in patients with renal cell carcinoma. Cancer Chemother Pharmacol. 2008; 61(4):689-694.


Hundley G, Hamilton C, Lane K, Morgan T, Torti F, inventors; Wake Forest University Health Sciences, assignee. Non-invasive imaging for determination of global tissue characteristics. United States patent US 7,333,845. 2008 Feb 19. 2008; ():.


Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I trial of angiotensin-(1-7): an endogenous anti-angiogenic hormone [abstract]. J Clin Oncol. 2008; 26(15 Suppl):634s.


Childers ML, Cho J, Regino CAS, Brechbiel MW, DiPasquale AG, Rheingold AL, Torti SV, Torti FM, Planalp RP. Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators. J Inorg Biochem. 2008; 102(1):150-156.


Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008; 65(11):1631-1652.


Coffman LG, Brown JC, Johnson DA, Parthasarathy N, D'Agostino RB Jr, Lively MO, Hua X, Willingham MC, Torti FM, Torti SV, et al. Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin. Am J Physiol Lung Cell Mol Physiol. 2008; 294(3):L505-L515.


Ryan CJ, Small EJ, Torti FM. Testicular cancer. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, eds. Abeloff's clinical oncology. 4th ed. Philadelphia: Churchill Livingstone/Elsevier; 2008: 1713-1744.


Anderson RT, Kimmick GG, Camacho F, Whitmire JT, Dickinson C, Levine EA, Torit FM, Balkrishnan R. Health system correlates of receipt of radiation therapy after breast-conserving surgery: a study of low-income Medicaid-enrolled women. Am J Manag Care. 2008; 14(10):644-652.


Blish KR, Wang W, Willingham MC, Du W, Brown JC, Hawkins GA, Garvin AJ, D'Agostino RB Jr, Torti FM, Torti SV, et al. A human bone morphogenetic protein antagonist is down-regulated in renal cancer. Mol Biol Cell. 2008; 19(2):457-464.


Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Bi-directional translational research with angiotensin-(1-7) uncovers placental growth factor as a therapeutic target [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research ; 2008 Apr 12-16; San Diego (CA). Philadelphia (PA): AACR. 2008; ():Abstr 4968.


Torti FM, Altieri D, Broach J, Fan H, Lotze M, Manfredi J, Matrisian L, Yu D, Giaccia A. Ph.D. training in cancer biology. Cancer Res. 2008; 68(22):9122-9124.


Zhang F, Wang W, Tsuji Y, Torti SV, Torti FM. Post-transcriptional modulation of iron homeostasis during P53-dependent growth arrest. J Biol Chem. 2008; 283(49):33911-18.


Jiao Y, Kennedy DP, Cho JH, Planalp R, Bou-Abdallah F, Chasteen ND, Wilkinson J, Wang W, Torti FM, Torti SV. Curcumin, a cancer chemopreventive agent, is a biologically relevant iron chelator [abstract]. Am J Hematol. 2007; 82(6):515.


Huber WW, Haslinger E, Schachner D, Parzefall W, Grasl-Kraupp B, Hochreiter A, Lang H, Torti SV, Torti FM, Schulte-Hermann R. The carcinogen azonymethane causes necrosis and oxidative stress in rat liver within 48 hours after injection, a toxic effect that is however strongly mitigated by pretreatment with the coffee components kahweol and cafestol [abstract]. Naunyn Schmiedebergs Arch Pharmacol. 2007; 375(Suppl 1):94.


Wang W, Di X, D'Agostino RB Jr, Torti SV, Torti FM. Excess capacity of the iron regulatory protein system. J Biol Chem. 2007; 282(34):24650-2465.


Han J, Seaman WE, Torti FM, Torti SV. Ferritin-mediated iron transport via TIM-2 in mouse kidney cells [abstract]. Am J Hematol. 2007; 82(6):517.


Li L, Torti SV, Torti FM, Hayashi S, Seaman WE. Structural requirements for the endocytosis of H-ferritin by murine TIM-2 [abstract]. Am J Hematol. 2007; 82(6):586.


Torti FM, Wang W, Di X, Torti SV. Extensive excess capacity of the IRP system in cellular iron regulation [abstract]. Am J Hematol. 2007; 82(6):565.


Torti FM, Coffman LG, Brown JC, Torti SV, Parthasarathy N, D'Agostino RB. Ferritin inhibits cleavage of high molecular weight kininogen by elastase and mast cell tryptase [abstract]. Am J Hematol. 2007; 82(6):508-509.


Storey JA, Torti FM. Bone metastases in prostate cancer: a targeted approach. Curr Opin Oncol. 2007; 19(3):254-258.


Torti SV, Byrne F, Whelan O, Levi N, Ucer B, Schmid M, Torti FM, Akman S, Liu J, Ajayan PM, et al. Thermal ablation therapeutics based on CN(x) multi-walled nanotubes. Int J Nanomedicine. 2007; 2(4):707-714.


Finkelman D, Torti FM, Lipton A, Hannon RA, Hussain A, Evans C, Akilu M, Iacona R, Swaisland A, Stuart M. A phase II pilot study of safety and effects on bone resorption of AZD0530 in prostate or breast cancer patients with bone metastases [abstract]. J Bone Miner Res. 2007; 22(Suppl 1):S409.


Storey JA, Connor R, Lewis ZT, Lovato J, Hurd D, Torti FM, Molnar I. The transfusion iron overload score is a potential predictor of survival in stem cell transplant patients [abstract]. Blood. 2007; 110(11 Pt 1):336A.


Borden LS Jr, Clark PE, Lovato J, Hall MC, Stindt D, Harmon M, Mohler RM, Torti FM. Vinorelbine, doxorubicin, and prednisone in androgen-independent prostate cancer. Cancer. 2006; 107(5):1093-1100.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Last Updated 8/12/2010
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