Profile

Contact & Referral

Research

Charles E. McCall, M.D.

Director, Translational Science Institute

Professor, Molecular Medicine

Translational Science Institute

Sticht Center on Aging

WFU Primate Center

Microbiology & Immunology

Infectious Diseases

Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Contact Information

Office:

336-716-2011

E-mail: chmccall@wfubmc.edu

Research Interests

educational service, epidemiology/prevention, translational research, cross(mult/tnslat/inter)discip, clinical trials, health services, research/outc

Recent Publications

Dynamic and selective nucleosome repositioning during endotoxin tolerance. El Gazzar M, Liu T, Yoza BK, McCall CE. J Biol Chem. 2010 285(2) : 1259-1271

Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BK. Shock. 2009 31(4) : 376-381

Chromatin-specific remodeling by HMGB1 and linker histone H1 silence proinflammatory genes during endotoxin tolerance. El Gazzar M, Yoza BK, Chen X, Garcia BA, Young NL, McCall CE. Mol Cell Biol. 2009 29(7) : 1959-1971

RelB sustains IkappaBalpha expression during endotoxin tolerance. Chen X, Yoza BK, El Gazzar M, Hu JYQ, Cousart SL, McCall CE. Clin Vaccine Immunol. 2009 16(1) : 104-110

The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance. Chen X, El Gazzar M, Yoza BK, McCall CE. J Biol Chem. 2009 284(41) : 27857-65

G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. El Gazzar M, Yoza BK, Chen X, Hu J, Hawkins GA, McCall CE. J Biol Chem. 2008 283(47) : 32198-208

Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Immunol Lett. 2007 111(1) : 36-44

Gene silencing in severe systemic inflammation. McCall CE, Yoza BK. Am J Respir Crit Care Med. 2007 175(8) : 763-767

Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE. Shock. 2007 28(4) : 447-452

Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance. El Gazzar M, Yoza BK, Hu JY-Q, Cousart SL, McCall CE. J Biol Chem. 2007 282(37) : 26857-64

Assembly of inflammation-related genes for pathway-focused genetic analysis. Loza MJ, McCall CE, Li L, Isaacs WB, Xu J, Chang B-L. PLoS ONE. 2007 2(10) : e1035

Induction of RelB participates in endotoxin tolerance. Yoza BK, Hu JY-Q, Cousart SL, Forrest LM, McCall CE. J Immunol. 2006 177(6) : 4080-4085

The pathogenesis of pulmonary contusion: an open chest model in the rat. Hoth JJ, Stitzel JD, Gayzik FS, Brownlee NA, Miller PR, Yoza BK, McCall CE, Meredith JW, Payne RM. J Trauma. 2006 61(1) : 32-45

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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