Profile

George J. Christ, Ph.D.

George J. Christ, Ph.D.

Professor, Institute for Regenerative Medicine
WFU Primate Center
Sticht Center on Aging
Physiology & Pharmacology
Urology
Contact Information
Office:
336-716-2011
E-mail: gchrist@wfubmc.edu
Research Interests
basic mechanisms, human, membranes/tissues/isola, women's health issues, education/training (all f, t,, musculoskeletal system, temporary, aging, atherosclerosis/thrombosis, engineering/bioengineering, human, adult, translational research, urinary system/kidney, animals, cells/membranes/tissu, neurosciences/behavior, reproductive system, biotechnology, educational service, nervous/sensory system/behavio, vascular diseases, animals, whole, cardiovascular system, technology /technique developm
Recent Publications
Localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity. Gratzke C, Christ GJ, Stief CG, Andersson K-E, Hedlund P. Eur Urol. 2010 57(2) : 342-349


Establishing a rodent model for characterization of natural in vivo bladder regeneration [abstract]. Burmeister D, AbouShwareb T, Andersson K, Christ G. Neurourol Urodyn. 2009 28(7) : 739-741


Altered camp-mediated potassium channel currents in detrusor myocytes from diabetic rats [abstract]. Zhao W, Brink P, Christ G. Neurourol Urodyn. 2009 28(7) : 744-745


Alterations in bladder function associated with urothelial defects in uroplakin II and IIIa knockout mice. Aboushwareb T, Zhou G, Deng F-M, Turner C, Andersson K-E, Tar M, Zhao W, D'Agostino R Jr, Sun T-T, Christ GJ, et al. Neurourol Urodyn. 2009 28(8) : 1028-1033


Gene transfer for erectile dysfunction: will this novel therapy be accepted by urologists?. Melman A, Rojas L, Christ G. Curr Opin Urol. 2009 19(6) : 595-600


Metrics for evaluation of age-related changes in erectile capacity in a rodent model. Zhao W, Sato Y, Melman A, Andersson KE, Christ G. J Sex Med. 2009 6(7) : 1885-1892


Regenerative pharmacology for diabetes mellitus. Furth ME, Christ GJ. Mol Interv. 2009 9(4) : 171-174


Smooth muscle cell seeding of decellularized scaffolds: the importance of bioreactor preconditioning to development of a more native architecture for tissue-engineered blood vessels. Yazdani SK, Watts B, Machingal M, Jarajapu YPR, Van Dyke ME, Christ GJ. Tissue Eng Part A. 2009 15(4) : 827-840


Smooth-muscle-specific gene transfer with the human Maxi-K channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys. Christ GJ, Andersson K-E, Williams K, Zhao W, D'Agostino R Jr, Kaplan J, Aboushwareb T, Yoo J, Calenda G, Davies KP, et al. Eur Urol. 2009 56(6) : 1055-1066


Bladder tissue regeneration [editorial]. Christ GJ. J Urol. 2009 182(1) : 16-17


Urinary protein profiles in a rat model for diabetic complications. Schlatzer DM, Dazard JE, Dharsee M, Ewing RM, Ilchenko S, Stewart I, Christ G, Chance MR. Mol Cell Proteomics. 2009 8(9) : 2145-2158


Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder. Gratzke C, Streng T, Park A, Christ G, Stief CG, Hedlund P, Andersson K-E. J Urol. 2009 181(4) : 1939-1948


Functional tissue engineering requires bioreactor strategies [preface]. Goldstein AS, Christ G. Tissue Eng Part A. 2009 15(4) : 739-740


Impact of diabetes and obesity on the prostate and urethra: implications to improved bladder dysfunction understanding and treatment. Christ GJ, Bushman W, Fraser MO. J Urol. 2009 182(6) : S38-S44


Mesenchymal stem cells: emerging therapy for Duchenne muscular dystrophy. Markert CD, Atala A, Cann JK, Christ G, Furth M, Ambrosio F, Childers MK. PM R. 2009 1(6) : 547-559


Voiding pattern analysis as a surrogate for cystometric evaluation in uroplakin II knockout mice. Hodges SJ, Zhou G, Deng F-M, Aboushwareb T, Turner C, Andersson K-E, Santago P, Case D, Sun T-T, Christ GJ. J Urol. 2008 179(5) : 2046-2051


Engineering muscularized vascular conduits [abstract]. Christ GJ. Tissue Eng Part A. 2008 14(5) : 848


Novel longitudinal studies of rat bladder regeneration [abstract]. Aboushwareb T, Burmeister D, Andersson KE, Christ GJ. Eur Urol Suppl. 2008 7(3) : 266


Threshold gene transfer with hSlo enhances sildenafil-induced erectile responses in 2-month streptozotocin (STZ)-diabetic rats [abstract]. Zhao W, Machigal M, Turner C, Davies K, Melman A, Andersson KE, Christ GJ. Eur Urol. 2008 7(3 Suppl) : 217


Cyclic mechanical preconditioning improves engineered muscle contraction. Moon DG, Christ G, Stitzel JD, Atala A, Yoo JJ. Tissue Eng Part A. 2008 14(4) : 473-482


Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat. Melman A, Biggs G, Davies K, Zhao W, Tar MT, Christ GJ. Gene Ther. 2008 15(5) : 364-370


The influence of electrospun aligned poly(epsilon-caprolactone)/collagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes. Choi JS, Lee SJ, Christ GJ, Atala A, Yoo JJ. Biomaterials. 2008 29(19) : 2899-2906


Chronic soy and phytoestrogen treatment leads to significant functional and morphological changes in the urethra of oophorectomized female non-human primates [abstract]. Gratzke C, Christ GJ, Kaplan JR, Stief CG, Andersson KE, Badlani G. Eur Urol. 2008 7(3 Suppl) : 315


MAXI-K gene transfer with a smooth muscle specific promoter enhances erectile function and sexual behaviour in atherosclerotic cynomolgous monkeys [abstract]. Christ GJ, Andersson K-E, Williams K, Zhao W, D'Agostino R, Kaplan J, Aboushwareb T, Yoo J, Davies K, Melman A. Eur Urol. 2008 7(3 Suppl) : 143


Smooth muscle cell seeding of decellularized scaffolds: further development toward a more native architecture for tissue engineered blood vessels [abstract]. Yazdani SK, Watts B, Machingal M, Jarajapu YPR, Van Dyke ME, Christ GJ. Tissue Eng Part A. 2008 14(5) : 778


Engineering of large diameter vessels. Yazdani SK, Christ GJ. Principles of regenerative medicine. 2008 : 978-999


Chronic soy and phytoestrogen treatment leads to significant functional and morphological changes in the urethra of female non-human primates [abstract]. Gratzke C, Christ GJ, Kaplan JR, Andersson K-E, Badlani G. Neurourol Urodyn. 2008 27(2) : 106


Proteomics analysis identifies molecular targets related to diabetes mellitus-associated bladder dysfunction. Yohannes E, Chang J, Christ GJ, Davies KP, Chance MR. Mol Cell Proteomics. 2008 7(7) : 1270-1285


Effects of long-term dietary soy treatment on female urethral morphology and function in ovariectomized nonhuman primates. Gratzke C, Jarajapu YPR, Christ GJ, Kaplan JR, Williams JK, Andersson K-E, Badlani G. J Urol. 2008 180(5) : 2247-2253


The future of bladder research: molecular profiling, new drug targets, gene therapy, and tissue engineering. Christ G, Andersson KE, Atala A. Curr Urol Rep. 2007 8(2) : 95-99


Urodynamic characterization of mice lacking uroplakin II or III [abstract]. Aboushwareb T, Zho G, Turner C, Andersson K-E, Tar M, Melman A, Deng F-M, Sun T-T, Christ GJ. FASEB J. 2007 21(6) : A1308


Regenerative pharmacology: the future is now. Andersson KE, Christ GJ. Mol Interv. 2007 7(2) : 79-86


Voiding patterns in uroplakin II knockout mice [abstract]. Hodges S, Zhou G, Deng F-M, Abouschwareb T, Turner C, Andersson K-E, Santago P, Sun H, Christ GJ. FASEB J. 2007 21(6) : A1301


Diabetes-induced changes in the alternative splicing of the Slo gene in corporal tissue. Davies KP, Zhao W, Tar M, Figueroa JC, Desai P, Verselis VK, Kronengold J, Wang H-Z, Melman A, Christ GJ. Eur Urol. 2007 52(4) : 1229-1237


Intravascular pressure causes novel synchronous intercellular Ca2+ oscillations in rat cerebral arteries [abstract]. Jarajapu YPR, Christ GJ, Knot HJ. FASEB J. 2007 21(6) : A1157


Diabetes-related alterations in cAMP-mediated potassium channel currents in short term cultures of detrusor myocytes [abstract]. Zhao W, Brink PR, Christ GJ. FASEB J. 2007 21(6) : A829


Bioreactor protocols for improved cellular penetration of decellularized scaffolds [abstract]. Yazdani SK, Jarajapu YPR, Machinga M [sic] [Machingal M], Watts B, Van Dyke ME, Christ GJ. Tissue Eng. 2007 13(7) : 1645


Threshold gene transfer with hSlo enhances sildenafil-induced erectile responses in 2 month streptozotocin(STZ)-diabetic rats [abstract]. Zhao W, Machingal M, Turner C, Davies K, Andersson K-E, Melman A, Christ GJ. FASEB J. 2007 21(5) : A420


Amniotic fluid derived stem cells for cardiac therapeutics [abstract]. Delo D, Neshat S, Christ G, Groban L, Olson J, Zhu J-M, Atala A, Soker S. FASEB J. 2007 21(5) : A229


Rho-kinase and effects of Rho-kinase inhibition on the lower urinary tract. Christ GJ, Andersson KE. Neurourol Urodyn. 2007 26(Suppl 6) : 948-954


Tissue bioreactor system for the creation and maturation of organized functional tissues for surgical reconstruction [abstract]. Moon DG, Tillman B, Christ G, Stitzel J, Yoo J, Atala A. J Am Coll Surg. 2007 205(3 Suppl) : S104


Using gene chips to identify organ-specific, smooth muscle responses to experimental diabetes: potential applications to urological diseases. Hipp JD, Davies KP, Tar M, Valcic M, Knoll A, Melman A, Christ GJ. BJU Int. 2007 99(2) : 418-430


Plasmid-based gene transfer for treatment of erectile dysfunction and overactive bladder: results of a phase I trial. Melman A, Bar-Chama N, McCullough A, Davies K, Christ G. Isr Med Assoc J. 2007 9(3) : 143-146


Progenitor cell-derived endothelial cell therapy restores diabetes associated erectile dysfunction [abstract]. Rodriguez S, Chen KL, Christ GJ, Yoo JJ, Atala A. J Urol. 2007 177(4 Suppl) : 264


Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats. Zotova EG, Christ GJ, Zhao W, Tar M, Kuppam SD, Arezzo JC. J Diabetes Complications. 2007 21(3) : 187-195


Functional enhancement of bioreactor assisted engineered skeletal muscle [abstract]. Zare S, Christ G, Moon DG, Zhao W, Atala A, Yoo JJ. Tissue Eng. 2007 13(7) : 1698


Mechanistic studies of detrusor over activity in male rats following partial urethral obstruction: implications to identification of novel therapeutics [abstract]. Aboushwareb T, Jarajapu YPR, Blaha S, Hodges S, Turner C, Zhao W, Andersson K-E, Christ GJ. FASEB J. 2007 21(6) : A1356


Functional enhancement of bioreactor assisted engineered skeletal muscle [abstract]. Zare S, Christ G, Moon DG, Zhao W, Atala A, Yoo JJ. FASEB J. 2007 21(5) : A135


Development of tissue engineered blood vessels with a functional medial muscle layer [abstract]. Yazdani SK, Jarajapu YPR, Machingal M, Watts B, Van Dyke ME, Christ GJ. Tissue Eng. 2007 13(7) : 1673


Pharmacological studies of AGI-1140 in a rat model of erectile dysfunction [abstract]. Aboushwareb T, Andersson K-E, Christ GJ. FASEB J. 2007 21(6) : A1159-1160


Smooth muscle seeded natural collagen scaffolds for tissue engineered blood vessels [abstract]. Yazdani SK, Machingal M, Watts B, Jarajapu YPR, Van Dyke ME, Christ GJ. FASEB J. 2007 21(5) : A81


Tissue bioreactor system for the creation and maturation of organized functional tissues for surgical reconstruction [abstract]. Moon DG, Christ GJ, Stitzel J, Yoo JJ, Atala A. J Urol. 2007 177(4 Suppl) : 58-59


Urodynamic studies in uroplakin II or III knockout (KO) mice [abstract]. Aboushwareb TA, Zhou G, Turner C, Andersson KE, Tar M, Melman A, Deng FM, Sun TT, Christ GJ. J Urol. 2007 177(4 Suppl) : 88


Amniotic fluid derived stem cells for cardiac therapeutics [abstract]. Neshat-Vahid S, Delo D, Milanesi A, Christ G, Atala A, Soker S. Eur Heart J. 2006 27(Suppl 1) : 19-20


Efficacy of weekly administration of hSlo (hMaxi-K) gene transfer for treatment of erectile dysfunction in aging rats [abstract]. Lowe D, Tar M, Du Hoffmann J, Christ GJ, Davies K, Melman A. J Urol. 2006 175(4 Suppl) : 223


Gap junction channel activity in short-term cultured human detrusor myocyte cell pairs: gating and unitary conductances. Wang H-Z, Brink PR, Christ GJ. Am J Physiol Cell Physiol. 2006 291(6) : C1366-1376


Experimental diabetes alters connexin43 derived gap junction permeability in short-term cultures of rat corporeal vascular smooth muscle cells. Brink PR, Valiunas V, Wang H-Z, Zhao W, Davies K, Christ GJ. J Urol. 2006 175(1) : 381-386


Results of the first human trial for genetransfer therapy for the treatment of erectile dysfunction [abstract]. Melman A, Bar-Chama N, McCullough AR, Davies K, Christ GJ. J Urol. 2006 175(4 Suppl) : 222


hMaxi-K gene transfer in males with erectile dysfunction: results of the first human trial. Melman A, Bar-chama N, McCullough A, Davies K, Christ G. Hum Gene Ther. 2006 17(12) : 1165-1176


Variable coding sequence protein A1 as a marker for erectile dysfunction. Tong Y, Tar M, Davelman F, Christ G, Melman A, Davies KP. BJU Int. 2006 98(2) : 396-401


Amniotic fluid derived stem cells for cardiac therapeutics [abstract]. Delo D, Neshat-Vahid S, Olson J, Zhu JM, Christ G, Atala A. Circulation. 2006 114(18 Suppl) : 197-198
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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