Study of the Effects of Low-Dose Radiation in the Treatment of Chronic Graft versus Host Disease

What we are studying

The purpose of this research study is to test the safety of low-dose total lymphoid irradiation (LD-TLI) and see what effects (good and bad) it has on you and your condition. In addition, we also want to see how LD-TLI affects your body’s immune system. Low-dose TLI is a procedure in which all of the body’s major lymph nodes are treated with small doses of radiation in order to “reset” your dysfunctional immune system.

Who is Eligible

  • Genders:
    • Men
    • Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18+

Eligibility Criteria

  • 18 years of age or older
  • Received a prior allogeneic hematopoietic stem cell transplant
  • Diagnosed with Chronic Grafts versus Host Disease

What is involved

  • You will be in the study for the length of time it takes to receive your treatment with LD-TLI and throughout the duration of your follow-up. You will have follow-up visits at
  • 45 days
  • 3 months
  • 6 months
  • 1 year
  • And every 6 months after that.



Contact Information

Study Coordinator
Vicki Lagerwey

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.