The A-4 Study

What we are studying

The A4 study is testing an investigational drug in older individuals who have evidence of elevated amyloid build-up in their brains, but who do not yet show symptoms of Alzheimer's disease (AD) in order to slow possible AD-related damage in the brain and to delay progression of AD-related memory loss. The purpose of this study is to test whether an investigational drug can slow the progression of memory problems associated with brain amyloid.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 65 - 85

Eligibility Criteria

  • Stable medications for 6 weeks prior to baseline visit
  • Has a study partner with at least weekly contact willing to attend visits and provide information about the participant
  • Willing and able to participate in all study procedures for the duration of the study
  • Has a PET scan that shows evidence of brain amyloid pathology at visit 2
  • Meets scoring criteria on memory assessments at screening
  • Women must have a negative pregnancy test (if not surgically sterile or post menopausal) on the day of PET imaging prior to the scan.

What is involved

  • 48 study visits over 36 months
  • Tests of memory and thinking skills
  • Height/Weight and vital signs
  • Physical and neurological exam
  • Electrocardiogram
  • Collection of general medical history
  • Review of medications
  • Blood and urine samples
  • Lumbar puncture (optional)
  • MRI
  • PET scan
  • Pregnancy test
  • Study drug administration through infusion.

Compensation

Participants will receive up to $330 upon completion of the study

Contact Information

Study Coordinator
Tim Collare
Email
rcollare@wakehealth.edu
Phone
336-716-6463
Principal Investigator
Suzanne Craft, PhD

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.