Clinical trial for older individuals who may be at risk for Alzheimer’s disease

What we are studying

The A4 study is testing an investigational drug in older individuals who have evidence of elevated amyloid build-up in their brains, but who do not yet show symptoms of Alzheimer's disease (AD) in order to slow possible AD-related damage in the brain and to delay progression of AD-related memory loss. The purpose of this study is to test whether an investigational drug can slow the progression of memory problems associated with brain amyloid.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 65 - 85

Eligibility Criteria

  • Stable medications for 6 weeks prior to baseline visit
  • Has a study partner with at least weekly contact willing to attend visits and provide information about the participant
  • Willing and able to participate in all study procedures for the duration of the study
  • Has a PET scan that shows evidence of brain amyloid pathology at visit 2
  • Meets scoring criteria on memory assessments at screening
  • Women must have a negative pregnancy test (if not surgically sterile or post menopausal) on the day of PET imaging prior to the scan.

What is involved

  • 48 study visits over 36 months
  • Tests of memory and thinking skills
  • Height/Weight and vital signs
  • Physical and neurological exam
  • Electrocardiogram
  • Collection of general medical history
  • Review of medications
  • Blood and urine samples
  • Lumbar puncture (optional)
  • MRI
  • PET scan
  • Pregnancy test
  • Study drug administration through infusion.

Contact Information

Study Coordinator
Erin Caulder
Email
ecaulder@wakehealth.edu
Phone
336-716-6463
Principal Investigator
Suzanne Craft, PhD

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.