What we are studying

Alzheimer’s disease (AD) is an irreversible disease that results in a loss of mental function due to the deterioration of brain tissue. Recent studies show that people with impaired memory may have problems with the way their bodies use blood sugar. These problems may be due in part to the way certain hormones, such as insulin, affect the body’s ability to use sugar. In people with Alzheimer’s disease, improvements in blood sugar regulation have been shown to improve the ability to remember new information. These findings provide some clues about what causes problems with memory, attention and concentration in some people with Alzheimer’s disease and other memory problems. The purpose of this research study is to evaluate whether a type of insulin (Humulin® R) improves memory when administered intranasally (as a “nasal spray”) to adults with a mild memory impairment or early Alzheimer’s disease.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 55 - 85

Eligibility Criteria

  • Diagnosed with Alzheimer’s disease (AD)

What is involved

  • There will be 11 clinic visits over the next 18 months
  • Give blood and urine samples (up to 5 times)
  • Take tests of memory
  • Thinking skills
  • Daily functioning and behavior (up to 8 times)
  • Have 3.0 Tesla Magnetic Resonance Imaging (3T MRI) scans of your brain (up to 2 times)
  • Undergo Lumbar Punctures (LPs) (up to 2 times)
  • Study drug will be administered twice a day
  • Study partner will need to attend at least 8 clinic visits


$100.00 per lumbar puncture and $25.00 for each clinic visit.

Contact Information

Study Coordinator
Tim Collare
Principal Investigator
Laura D. Baker, PhD

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.