Preventing Heart Problems During and After Surgery

What we are studying

Major surgeries not involving the heart are common and major heart problems during or after such surgeries represent a large population health problem. Few treatments to prevent heart problems around the time of surgery have been tested. There is encouraging data suggesting that small doses of Acetyl-Salicylic Acid (Aspirin or ASA) and Clonidine, which are two medications, given individually for a short period before and after major surgeries may prevent major heart problems. This trial will give us information to help us determine if ASA and Clonidine can prevent heart attacks and deaths from heart problems around the time of surgery. ASA and Clonidine are both FDA approved medications.

Who we are studying

  • Men and Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 45+

Eligibility Criteria

  • Undergoing surgery
  • Have at least one of the following:
    • History of coronary artery disease
    • History or peripheral vascular disease
    • Undergoing major vascular surgery
  • Or have any three of the following:
    • Undergoing major surgery
    • History of congestive heart failure
    • Transient ischemic attack (TIA)
    • Diabetes
    • Age 70 or older
    • High blood pressure
    • High creatinine
    • History of smoking within 2 years
    • Undergoing emergent surgery

What is involved

  • Screening during a doctor visit prior to surgery
  • Receive study medication prior to surgery and for 7 to 30 days after
  • Blood samples right after the surgery and the 3 days after
  • Phone call follow-up at 1 month and 1 year after surgery



Contact Information

Study Coordinator
Peggy Jordan

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.